Not only is the dog apparently suffering, but the neighbors are for sure suffering. Perhaps a visit to the substation on Blatchley is in order so that you can find out what your options are. Perhaps you can talk to the neighbors and get a calling campaign going with the police non-emergency number. And after 10 PM, perhaps you can make a formal complaint calling into effect the noise law violation. Is the animal at all aggressive? If so you surely have a strong case for getting at least an evaluation from animal control as to whether or not the dog is a danger. Maybe even a cruelty complaint can be lodged? And maybe banging on the door at 2 in the morning to request that they silence the dog would clue them in to your displeasure. Perhaps if they do not care about the dog's discomfort they will care about their own. Would be nice if you could talk to your neighbors and get them all in on the action. If you can find out who the owner of the house is, some serioius communication with him/her may be in order. What about the Livable Something Initiative which deals with quality of life issues? You have my sympathy for sure.